Science geek Rusty Cartwright (Jacob Zachar) begins his freshman year at the same university his popular sister Casey (Spencer Grammer) attends in Season 1 of this comedy-drama focusing on a group of students who belong to fraternities and sororities. Casey is a big deal at her sorority Zeta Beta Zeta, and much to her chagrin, Rusty decides he also wants to become a part of Cyprus-Rhodes University's Greek life. He initially plans to pledge Omega Chi, where Casey's boyfriend, blue-blooded Evan (Jake McDorman), is a member. However, Rusty catches Evan cheating on Casey with ZBZ pledge Rebecca (Dilshad Vadsaria), a senator's daughter. When Rusty tells his sister about Evan's infidelity, he ruins his chances at Omega Chi and joins Kappa Tau, where laid-back Cappie (Scott Michael Foster) is president. Cappie is Evan's former best friend and Casey's ex-boyfriend, which makes things complicated. Life soon gets complicated for Rusty as well when he tries to balance Greek life with honors classes and friendships. Rusty's roommate is pious Dale (Clark Duke), who chooses not to pledge a fraternity, and Rusty's new best bud is Calvin (Paul James), an athletic Greek legacy who becomes an Omega Chi brother. Calvin doesn't initially tell his new brothers that he is gay, but then bubbly ZBZ sister Ashleigh (Amber Stevens) accidentally outs him to his fraternity. Calvin begins secretly dating pre-med major Heath (Zack Lively), and Rusty starts a relationship with his first girlfriend, ZBZ pledge Jen K (Jessica Rose). However, Jen K does something that causes a scandal within the Greek system, and it forces ZBZ president Frannie (Tiffany Dupont) to step down. Casey then becomes ZBZ president, but it's at a time when her romantic life is going downhill---she and Evan break up, and she learns Cappie is dating Rebecca. Meanwhile, Dale forms a new club: U-SAG (University Students Against Greeks).